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Fig. 10B. —Contrast medium concentrations as results of three-compartment model
calculations and CT measurements in patient with markedly swollen kidneys
(shown in Figs. 8A,
8B) caused by bilateral
pyelonephritis with hydronephrosis and treated with percutaneous nephrostomy
on left side. Patient had low glomerular filtration rate (GFR). Interstitial
space was calculated to be 46%. Parameters are more fully defined in Appendix
1. Graph shows contrast medium amount in vascular space, B(t)
(
); in interstitial space, I(t) (
); and excreted into
nephron as result of model calculations and CT measurements. Amount of
contrast medium in interstitial space is much greater than amount excreted
into nephron. Most contrast medium measured with CT (KCT)
represents contrast medium in interstitial space. Calculated Patlak plot
[3] is curved line with slope
that is initially steep and later flattens. • = amount of contrast medium
in nephron, N(t); 
= amount of contrast medium in kidney,
K(t); 
= contrast medium measured with CT
(KCT).
