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Fig. 4B. —49-year-old woman with history of lobular carcinoma in situ (LCIS). Sagittal T1-weighted contrast-enhanced image of right breast after vacuum-assisted biopsy shows air (arrow) at biopsy site. Anterior aspect of lesion has been sampled. Note washout of contrast material from lesion and progressive enhancement of parenchyma, decreasing lesion conspicuity. Histologic analysis of vacuum-assisted biopsy specimens revealed markedly atypical ductal hyperplasia arising in background of radial sclerosing lesions and columnar cell change, as well as LCIS involving areas of mammary sclerosing adenosis. Surgical excision yielded low-grade cribriform ductal carcinoma in situ, markedly atypical ductal hyperplasia arising in background of mammary sclerosing adenosis and columnar cell change, and extensive LCIS.

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