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Fig. 3A. Graphs show correlation between computer output and average radiologists' ratings without and with computer-aided diagnosis (CAD) scheme for indicating likelihood of malignancy for lung nodules. = average radiologists' ratings for malignant nodules, {circ} = average radiologists' ratings for benign nodules, horizontal lines = range of radiologists' ratings for each nodule. Graphs show correlation between computer outputs and average radiologists' ratings without CAD (A) (r = 0.514) and with CAD (B) (r = 0.784). Note that radiologists' ratings without CAD scheme in some malignant (upper left quadrant) and benign (lower right quadrant) nodules were obviously correct, whereas likelihood of malignancy based on computer outputs alone was incorrect; even with incorrect CAD outputs, radiologists retained correct ratings. One malignant case (arrow) and one benign case (arrowhead) shown here are illustrated in Figures 4A, 4B.





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