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Fig. 7A. —Proposal models for effects of lymphangioleiomyomatosis (LAM)
on lymphatics. Models of effect of LAM on lymphatics show normal lymphatic
vessel with unidirectional valve and normal direction of lymph flow
(arrows) (a), proliferation of abnormal smooth-muscle cells (LAM
cells) on walls of lymphatic that causes mural thickening and luminal
narrowing (b), and obstruction of lymph flow by LAM cells that results in
dilatation of lymphatic proximal to obstruction, creating lymphangioleiomyoma
(c).
