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Fig. 2B —Use of T1-weighted dynamic contrast-enhanced technique to
evaluate permeability in patient with residual high-grade glioma after
previous resection. Technique uses dynamic contrast-enhanced 3D spoiled
gradient imaging sequence obtained every 6.45 sec for 58 sec after IV infusion
of 0.1 mmol/kg of gadopentetate dimeglumine. Before contrast material
infusion, five unenhanced T1-weighted spoiled gradient images are obtained,
each using different flip angle to derive T1 values of tissue needed for
analysis of permeability. Quantitative color-coded Ktrans (volume
transfer constant between blood plasma and extravascular extracellular space,
min-1) map obtained at same location as A showing range of
Ktrans values from 0.0 min-1 (dark end of scale) to 0.1
min-1 (bright end of scale) shows marked increase in permeability
within much of periphery of tumor. (Map of Ktrans generated using
TOPPCAT software) [29]. (Image
provided courtesy of Daniel Barboriak, MD)
