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DOI:10.2214/AJR.06.0785
AJR 2006; 187:S457-S459
© American Roentgen Ray Society

Imaging Evaluation of Adnexal Masses: Self-Assessment Module

Susanna I. Lee1

1 Department of Radiology, Massachusetts General Hospital, 55 Fruit St., White 270, Boston, MA 02114.

Received June 14, 2006; accepted after revision June 16, 2006.

 
Address correspondence to S. I. Lee (slee0{at}partners.org).


Abstract
Top
Abstract
INTRODUCTION
EDUCATIONAL OBJECTIVES
REQUIRED READING
INSTRUCTIONS
References
 
The educational objectives for this self-assessment module on adnexal masses are for the participant to exercise, self-assess, and improve his or her knowledge of the imaging evaluation of adnexal masses and to gain familiarity with the features of adnexal masses on sonography and MRI that characterize them as benign.

Keywords: adnexal masses • genitourinary tract imaging • MRI • reproductive organ imaging • sonography


INTRODUCTION
Top
Abstract
INTRODUCTION
EDUCATIONAL OBJECTIVES
REQUIRED READING
INSTRUCTIONS
References
 
This self-assessment module on the evaluation of adnexal masses has an educational component and a self-assessment component. The educational component consists of five required articles that the participant should read. The self-assessment component consists of six multiple-choice questions with solutions. All of these materials are available on the ARRS Web site (www.arrs.org). To claim CME and SAM credit, each participant must enter his or her responses to the questions online.


EDUCATIONAL OBJECTIVES
Top
Abstract
INTRODUCTION
EDUCATIONAL OBJECTIVES
REQUIRED READING
INSTRUCTIONS
References
 
By completing this educational activity the participant will:

  1. Exercise, self-assess, and improve his or her knowledge of the diagnostic features of adnexal masses on transvaginal sonography and pelvic MRI.
  2. Improve his or her knowledge of which adnexal masses can be definitively characterized as benign with imaging.


REQUIRED READING
Top
Abstract
INTRODUCTION
EDUCATIONAL OBJECTIVES
REQUIRED READING
INSTRUCTIONS
References
 
(available at www.arrs.org)

  1. Lee SI. Radiological reasoning: imaging characterization of bilateral adnexal masses. AJR 2006;187 [suppl]:S460-S466[Abstract/Free Full Text]
  2. Ha HK, Lim YT, Kim HS, Suh TS, Song HH, Kim SJ. Diagnosis of pelvic endometriosis: fat-suppressed T1-weighted versus conventional MR images. AJR 1994;163 :127-131[Abstract/Free Full Text]
  3. Jain KA. Imaging of peritoneal inclusion cysts. AJR 2000;174 :1559-1563[Free Full Text]
  4. Patel MD, Feldstein VA, Lipson SD, Chen DC, Filly RA. Cystic teratomas of the ovary: diagnostic value of sonography. AJR 1998;171 :1061-1065[Abstract/Free Full Text]
  5. Jung SE, Rha SE, Lee JM, et al. CT and MRI findings of sex cord-stromal tumor of the ovary. AJR2005 ;185 :207-215[Abstract/Free Full Text]


INSTRUCTIONS
Top
Abstract
INTRODUCTION
EDUCATIONAL OBJECTIVES
REQUIRED READING
INSTRUCTIONS
References
 

  1. Complete the required reading.
  2. Visit www.arrs.org and select the Journals/Integrative Imaging link on the left-hand side of the home page.
  3. Using your member login, order the online SAM as directed.
  4. Follow the online instructions for entering your responses to the self-assessment questions and complete the test by answering the questions online.


QUESTION 1

Sonogram shows an adnexal lesion that is homogeneously solid. What lesion should NOT be included in the differential diagnosis?

  1. Dermoid.
  2. Endometrioma.
  3. Fibroma.
  4. Peritoneal inclusion cyst.
  5. Metastasis.

QUESTION 2

Which MRI feature is NOT seen in benign endometrioma of the adnexa?

  1. Homogeneous T1 hyperintensity on fat-suppression sequences.
  2. Heterogeneous T1 hyperintensity on fat-suppression sequences.
  3. T2 hypointensity on fast spin-echo sequences.
  4. T1 isointense nodules that enhance with gadolinium.
  5. T2 hyperintensity on fast spin-echo sequences.

QUESTION 3

Which MRI pulse sequence is most sensitive in detecting pelvic endometriosis?

  1. T1-weighted without fat saturation.
  2. T1-weighted with fat saturation.
  3. T2-weighted fast spin echo.
  4. Gadolinium-enhanced T1-weighted with fat saturation.
  5. Inversion recovery.

 

Solution to Question 1
Fibroma is the most common sex cord stromal tumor of the ovary and typically appears as a well-defined, hypoechoic mass on sonography [1]. Endometriomas show a spectrum of appearances on sonography, including a solid-appearing ovarian lesion with diffuse low-level internal echoes [2]. Dermoids manifest a variety of appearances and, when small, can appear as homogeneously solid echogenic ovarian masses [3]. Metastases to the ovary may appear as homogeneously solid masses. Peritoneal inclusion cysts typically appear as loculated collections of fluid surrounding but not obliterating an ovary [4]. Although these cysts can sometimes show solid components—for example, septations or mural nodularity—they are predominantly cystic and are never homogeneously solid. Option D is the best response.


QUESTION 4

Which lesion generally requires histopathologic examination in order to make a definitive diagnosis?

  1. Endometrioma.
  2. Peritoneal inclusion cyst.
  3. Cystadenoma.
  4. Broad-ligament fibroid.
  5. Dermoid.

QUESTION 5

A woman undergoes sonography to evaluate an adnexal mass. In which circumstance would further imaging by MRI be redundant and not contribute to management?

  1. Simple unilocular cyst.
  2. Homogeneously solid ovarian mass.
  3. Cyst with regional bright echoes and acoustic shadowing.
  4. Cyst with diffuse low-level echoes and hyperechoic wall foci.
  5. Multilocular cyst surrounding an intact ovary.

QUESTION 6

A sonographic examination reveals a 5-cm complex cyst with reticular thin septations in the right ovary of a premenopausal woman. What is the most appropriate next management step?

  1. Repeat transvaginal sonography in 6 weeks.
  2. MRI.
  3. CT.
  4. Surgical resection.
  5. Radiography.

 

Solution to Question 2
Endometriomas contain high concentrations of paramagnetic products of hemoglobin breakdown. Consequently, they are intensely T1 hyperintense and show no decrease in signal with fat-suppression pulse sequences [5]. On T2-weighted images, they can show the spectrum of signal intensities from hypointense to hyperintense. Endometriomas with T1 hypo- or isointense components that enhance with gadolinium should be regarded as suspicious for malignant degeneration [6]. Benign endometriomas should not show gadolinium enhancement. Option D is the best response.

Solution to Question 3
Ovarian endometriomas and extraperitoneal endometriotic implants can show a variety of appearances on MRI. However, extremely high T1 signal that is homogeneously bright is considered diagnostic of an endometrioma and endometriosis. Because they are "light-bulb" bright in the surrounding dark pelvic soft tissue, endometriomas and endometriotic implants are particularly easy to spot on fat-saturated T1-weighted images [5]. Option B is the best response. The conspicuity of endometriomas is decreased on T1-weighted sequences without fat saturation, on which there is surrounding bright signal from fat, and on gadolinium-enhanced T1-weighted sequences, on which normal enhancing tissue and vessels appear bright. Endometriosis shows no characteristic features on T2-weighted or inversion recovery sequences.

Solution to Question 4
Although they can show a spectrum of features, the characteristic endometrioma is a well-defined, usually cystic lesion with diffuse low-level internal echoes on sonography [2] and is homogeneously "light-bulb" bright on T1-weighted fat-saturated MR images [5]. Peritoneal inclusion cysts typically are loculated collections of fluid surrounding but not obliterating the ovary [4]. Although benign ovarian cystadenomas typically present as large (> 3 cm) complex cystic masses with solid components—that is, with thick septations or mural nodularity of papillary projections—they cannot be differentiated from malignant ovarian tumors on imaging features alone. Option C is the best response. Broad-ligament fibroids typically appear as completely solid well-circumscribed adnexal masses separate from the ovary [7]. Dermoids are characterized by macroscopic fat that can be definitively characterized on MR fat-suppression sequences.

Solution to Question 5
Simple unilocular cysts—cysts with an imperceptible wall and no solid components—require no further imaging evaluation when presenting in a premenopausal woman. Although they can rarely be a benign epithelial tumor—for example, cystadenoma—they are usually physiologic ovarian cysts or inclusion cysts and are not malignant [8]. Option A is the best response. Homogeneously solid masses on sonography could be further characterized as a fibroma, endometrioma, or dermoid on MRI. Dermoids can appear as cysts with regional bright echoes [3] and acoustic shadowing, and endometriomas can appear as cysts with diffuse low-level echoes and hyperechoic wall foci [2]. Peritoneal inclusion cysts characteristically appear as multiloculated collections of fluid surrounding an intact ovary. If sonographic findings are equivocal, MRI can be helpful in more definitively characterizing all of these lesions.

Solution to Question 6
The lesion described is characteristic of a hemorrhagic physiologic cyst [9]. It should significantly decrease in size or completely disappear on follow-up sonography after a single menstrual cycle. Option A is the best response. Follow-up imaging is necessary because this is a large (i.e., > 3-4 cm) mixed and solid cystic ovarian lesion that cannot be distinguished from a malignancy with complete certainty on a single imaging study. Although hemorrhagic cysts can show blood products, they lack any characteristic appearance on CT or MRI that allows discrimination from a neoplasm that has bled. Surgical resection should be reserved for ovarian lesions that persist or grow on follow-up imaging and that show no features on sonography indicating that they could be definitively characterized as benign on MRI. Radiography has no role in the evaluation of an adnexal lesion.


References
Top
Abstract
INTRODUCTION
EDUCATIONAL OBJECTIVES
REQUIRED READING
INSTRUCTIONS
References
 

  1. Stephenson WM, Laing FC. Sonography of ovarian fibromas. AJR 1985; 144:1239 -1240[Abstract/Free Full Text]
  2. Patel MD, Feldstein VA, Chen DC, Lipson SD, Filly RA. Endometriomas: diagnostic performance of US. Radiology1999; 210:739 -745[Abstract/Free Full Text]
  3. Patel MD, Feldstein VA, Lipson SD, Chen DC, Filly RA. Cystic teratomas of the ovary: diagnostic value of sonography. AJR 1998; 171:1061 -1065[Abstract/Free Full Text]
  4. Jain KA. Imaging of peritoneal inclusion cysts. AJR 2000; 174:1559 -1563[Free Full Text]
  5. Ha HK, Lim YT, Kim HS, Suh TS, Song HH, Kim SJ. Diagnosis of pelvic endometriosis: fat-suppressed T1-weighted vs. conventional MR images. AJR 1994; 163:127 -131[Abstract/Free Full Text]
  6. Tanaka YO, Yoshizako T, Nishida M, Yamaguchi M, Sugimura K, Itai Y. Ovarian carcinoma in patients with endometriosis: MR imaging findings. AJR 2000; 175:1423 -1430[Abstract/Free Full Text]
  7. Weinreb JC, Barkoff ND, Megibow A, Demopoulos R. The value of MR imaging in distinguishing leiomyomas from other solid pelvic masses when sonography is indeterminate. AJR 1990;154 : 295-299[Abstract/Free Full Text]
  8. Modesitt SC, Pavlik EJ, Ueland FR, DePriest PD, Kryscio RJ, van Nagell JR Jr. Risk of malignancy in unilocular ovarian cystic tumors less than 10 centimeters in diameter. Obstet Gynecol2003; 102:594 -599[Abstract/Free Full Text]
  9. Baltarowich OH, Kurtz AB, Pasto ME, Rifkin MD, Needleman L, Goldberg BB. The spectrum of sonographic findings in hemorrhagic ovarian cysts. AJR 1987;148 : 901-905[Abstract/Free Full Text]

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