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Figure 1


Fig. 1 Flowchart shows methodologic approach followed by each reviewer to evaluate interobserver variability in assessment of right ventricular ejection fraction (RVEF) with MDCT. First step was to investigate influence of operator technique on determination of reconstruction window for diastolic and systolic phases, assessed by comparing concordant and discordant selections between reviewer 1 and reviewer 2 in step 1, reconstruction window. Interobserver variability in manual segmentation process was evaluated by comparing end-systolic (ESV) and end-diastolic (EDV) right ventricular volumes obtained by each reviewer after concordant selections of reconstruction windows by both reviewers (step 2, segmentation process).The variability of RVEF measurements with CT was investigated by comparing each reviewer's measurement on MDCT with that obtained on equilibrium radionuclide ventriculography (step 3, MDCT vs scintigraphy). Agreements between two reviewers and between MDCT and scintigraphy were assessed by means of intraclass correlation coefficient. Agreement was also assessed by Bland-Altman method and by mean absolute percent error.





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