DOI:10.2214/AJR.06.1191
AJR 2006; 187:S500-S504
© American Roentgen Ray Society
CT and MRI of Coronary Artery Disease: Self-Assessment Module
Anil K. Attili1,
Jonathan M. Foral2,
U. Joseph Schoepf3,
Philip N. Cascade1 and
Felix S. Chew4
1 Department of Radiology, University of Michigan, Ann Arbor, MI
48109-0302.
2 Department of Radiology, Harborview Medical Center, Seattle, WA 98104.
3 Department of Radiology, Center for Advanced Imaging Research, Medical
University of South Carolina, Charleston, SC 29425.
4 Department of Radiology, University of Washington, Box 354755, 4245 Roosevelt
Way NE, Seattle, WA 98105.
Received September 6, 2006;
accepted after revision September 6, 2006.
Address correspondence to F. S. Chew
(fchew{at}u.washington.edu).
ARRS members earn free CME and SAM credit at
www.arrs.org.
Select Journals/Integrative Imaging from the navigation menu on the left of
the home page.
Abstract
The educational objectives for this self-assessment module on CT and MRI of
coronary artery disease are for the participant to exercise, self-assess, and
improve his or her knowledge of the clinical applications of CT and MRI in
evaluating coronary artery disease.
Keywords: cardiac imaging coronary artery disease CT angiography MDCT MRI
INTRODUCTION
This self-assessment module on CT and MRI of coronary artery disease has an
educational component and a self-assessment component. The educational
component consists of two required articles that the participant should read.
The self-assessment component consists of seven multiple-choice questions with
solutions. All of these materials are available on the ARRS Web site
(www.arrs.org).
To claim CME and SAM credit, each participant must enter his or her responses
to the questions online.
EDUCATIONAL OBJECTIVES
By completing this educational activity, the participant will: A. Exercise,
self-assess, and improve his or her knowledge of the clinical application of
CT to diseases of the coronary arteries. B. Exercise, self-assess, and improve
his or her knowledge of the clinical application of MRI to diseases of the
coronary arteries.
REQUIRED READING
(available at
www.arrs.org)
- Attili AK, Cascade PN. CT and MRI of coronary artery disease:
evidence-based review. AJR 2006; 187[suppl]:S483-S499
- Schoepf UJ. CT angiography of the coronary arteries. In: McAdams HP, Reddy
GP, eds. Cardiopulmonary imaging: categorical course syllabus.
Leesburg, VA: American Roentgen Ray Society, 2005:151-160
INSTRUCTIONS
- Complete the required reading.
- Visit
www.arrs.org
and select the Journals/Integrative Imaging link on the left-hand side of the
home page.
- Using your member login, order the online SAM as directed.
- Follow the online instructions for entering your responses to the
self-assessment questions and complete the test by answering the questions
online.
| QUESTION 1
Regarding coronary artery anomalies, which statement is TRUE?
- Anomalous origin of the right coronary artery from the left sinus of
Valsalva is clinically benign.
- The stress ECG is highly sensitive in detecting coronary artery
anomalies.
- Catheter angiography is the imaging technique of choice for a suspected
coronary artery anomaly.
- Myocardial bridging manifests as fixed narrowing of the affected coronary
artery segment.
- Anomalous origin of the left coronary artery from the right sinus of
Valsalva is a high-risk lesion for sudden death.
QUESTION 2
Regarding coronary artery aneurysms, which statement is TRUE?
- Atherosclerosis is the most common cause worldwide.
- The left main coronary artery is the most common site of occurrence.
- Eighty percent of patients with Kawasaki disease develop coronary artery
aneurysms.
- Catheter angiography is the gold standard for determining their true
size.
- Myocardial infarction may be caused by secondary thromboembolism.
QUESTION 3
After a myocardial infarction, which imaging technique is most likely to
distinguish irreversibly injured myocardium from dysfunctional but viable
myocardium?
- Unenhanced CT for calcium scoring.
- Enhanced CT with pharmacologic stress.
- Delayed contrast-enhanced MRI.
- Echocardiography.
- Catheter angiography.
QUESTION 4
Regarding the technique of delayed contrast-enhanced MRI, which of the
following statements is TRUE?
- With delayed enhancement imaging, fibrous tissue actively takes up
gadolinium.
- Delayed enhancement imaging typically uses a T1-weighted spin-echo
sequence.
- With an appropriate inversion time, the signal intensity of normal
myocardium should be close to null.
- A 2D sequence results in more motion artifact than a 3D sequence.
- IV-injected gadolinium remains in the intravascular space unless there is
capillary leakage.
QUESTION 5
Regarding CT angiography technique, which of the following is
TRUE?
- Beta-blockers may improve image quality by decreasing a patient's heart
rate.
- The right coronary artery is best depicted in images reconstructed in late
or end-diastole.
- In patients with high calcium scores (> 75th percentile), CT angiography
is accurate for evaluating coronary artery stenosis.
- The effective radiation dose from uncomplicated conventional angiography is
greater than CT angiography.
- CT angiography has a higher spatial and temporal resolution than
conventional catheter angiography.
QUESTION 6
When is contrast-enhanced CT angiography of the coronary arteries NOT
indicated?
- Evaluation of the patency of a coronary artery bypass graft.
- Noninvasive detection of coronary artery stenosis.
- Suspected coronary artery anatomic anomalies.
- Acute myocardial infarction with elevated cardiac enzymes and diagnostic
ECG changes.
- Pulmonary vein imaging in the context of ablation therapy for ectopic
electrical activity.
QUESTION 7
Regarding coronary CT angiography (CTA) as a triage tool for acute chest
pain in the emergency department, which statement is TRUE?
- Single-detector CT is adequate to assess the coronary arteries in the
emergent setting.
- It is indicated in patients with a high pretest probability of coronary
artery disease.
- Extending the protocol to include the pulmonary arteries and the thoracic
aorta is an area of current investigation.
- Negative findings on coronary CTA require conventional catheter angiography
to exclude significant coronary artery disease.
- Acute chest pain as a presenting symptom is usually caused by a coronary
syndrome.
|
Solution to Question 1
Congenital anomalies of the coronary arteries that are associated with
increased risk of myocardial ischemia and sudden death are classified as
malignant; those that are not associated with such a risk are classified as
benign. The most common of the malignant anomalies is origin of the right
coronary artery from the left sinus of Valsalva. Option A is not the best
response.
The stress ECG can be normal in the presence of coronary artery anomalies
and is not considered reliable as a screening test
[1]. Option B is not the
best response.
Coronary artery anomalies are often difficult to fully characterize on
catheter angiography. Both CT angiography
[2] and MR angiography can
identify and characterize anomalous coronary arteries with a higher accuracy
than catheter angiography [3,
4]. Option C is not the best
response.
An epicardial segment of a coronary artery that courses through the
myocardium is termed "myocardial bridging." With myocardial
bridging, the involved coronary artery is compressed in systole. The clinical
significance of myocardial bridges is uncertain, but generally, myocardial
bridging is considered a benign condition because most coronary flow occurs
during diastole. However, myocardial bridging has been reported as a cause of
angina, ischemia, or infarction
[5]. Option D is not the
best response.
Sudden death, usually during or shortly after vigorous exertion, may be the
first clinical manifestation in patients with ectopic coronary artery origin,
such as an anomalous left coronary artery arising from the right sinus
[6]. However, warning symptoms
such as chest pain and syncope may occur in a substantial proportion of these
individuals. Option E is the best response.
Solution to Question 2
Coronary artery aneurysms are defined as segments of vessels with a
diameter greater than 1.5 times that of the normal adjacent artery segment;
they can be classified as fusiform or saccular
[7]. Kawasaki disease is the
most frequent cause of coronary aneurysms worldwide, whereas atherosclerotic
coronary disease is the most common cause in the United States. Option A is
not the best response.
The most commonly affected coronary artery segments are, in order of
frequency, the proximal and mid portions of the right coronary artery, the
proximal portion of the left anterior descending artery, and the proximal
portion of the circumflex coronary artery. Aneurysms of the left main coronary
trunk are unusual [8].
Option B is not the best response.
Kawasaki disease is an acute vasculitis of infancy and childhood. When
Kawasaki disease is untreated, only 15-25% of patients develop coronary artery
aneurysms [9]. When the disease
is treated with corticosteroids, the incidence of aneurysms is even lower.
Option C is not the best response.
The true size of an aneurysm may be underestimated on catheter angiography
if the aneurysm contains substantial thrombus. ECG-gated CT allows more rapid
and accurate delineation of the size and shape of aneurysms
[10]. MRI offers an
alternative imaging technique for evaluating coronary artery aneurysms, but
the spatial resolution of MRI is inferior to that of CT. Option D is not
the best response.
Myocardial infarction may be caused by thromboembolism from coronary artery
aneurysms. Option E is the best response.
Solution to Question 3
Identification of irreversibly injured myocardium from dysfunctional, but
viable and potentially salvageable, myocardium is of crucial importance for
the management of cardiac patients. Revascularization of an infarcted area is
justified only if the patient is likely to benefit from the procedure. Delayed
contrast-enhanced MRI is an excellent tool to evaluate myocardial viability
and differentiate between patients who are likely to benefit from
revascularization and patients who are not likely to benefit
[11,
12]. Dysfunctional,
predominantly viable segments will have no or minimal hyperenhancement,
whereas predominantly scarred segments will show extensive hyperenhancement.
Dysfunctional segments with extensive enhancement on delayed contrast-enhanced
MRI are unlikely to exhibit functional recovery after percutaneous or surgical
revascularization. Option C is the best response.
Calcium scoring has no role in the evaluation of myocardial viability.
Calcium scoring is used as a risk factor for coronary artery disease.
Option A is not the best response.
Enhanced CT with pharmacologic stress, echocardiography, and catheter
angiography may show dysfunctional myocardial motion, but those techniques do
not evaluate myocardial viability. Options B, D, and E are not the best
responses.
Solution to Question 4
The delayed contrast-enhanced MRI technique for detection of myocardial
viability relies on the extracellular distribution of gadolinium chelates in
the myocardium. In regions with increased extracellular space (e.g.,
infarction and fibrosis), higher concentrations of gadolinium accumulate, with
concomitant slower clearance and higher signal on delayed enhancement
sequences [13]. Option A is
not the best response.
The typical pulse sequence for myocardial delayed enhancement is an
inversion recovery-prepared segmented gradient-echo sequence, which exhibits
an increased signal intensity of tissue that is superior to other imaging
techniques such as spin-echo techniques
[14]. Option B is not the
best response.
"Nulling" of the normal myocardium is critical if areas of
hyperenhancement are to be properly displayed. The gradient-echo technique
used consists of an inversion prepulse chosen so that there is no or little
longitudinal magnetization in the normal myocardium. Selection of the
appropriate inversion time is crucial. In clinical settings, this is usually
performed visually by applying a 2D inversion sequence with variable prepulse
delays (200-300 milliseconds in steps of 25 milliseconds) or a Look-Locker
sequence. The optimal TI (time to inversion) is the delay with the best visual
suppression of myocardium. The typical signal intensity is a dark myocardium,
a slightly brighter blood pool, and a very bright infarct. Option C is the
best response.
Three-dimensional sequences are subject to more motion artifact because of
the larger number of k-space lines that must be acquired compared with 2D
sequences. Option D is not the best response.
IV-injected gadolinium rapidly diffuses into the extracellular space,
regardless of whether there is capillary leakage. Option E is not the best
response.
Solution to Question 5
A slow, regular heart rate increases the portion of the cardiac cycle spent
quietly in diastole and is ideal for image quality. Heart rates greater than
65 beats per minute increase motion artifacts and reduce the image quality of
portions of the coronary arteries, particularly the right coronary artery.
Premedication with ß-adrenergic receptor blocking agents
(ß-blockers) is recommended to reduce the heart rate before CT
angiography [15], particularly
in patients with heart rates greater than 65 beats per minute.
Contraindications for ß-blocker therapy include asthma, atrioventricular
conduction block, heart failure, diabetes, and Raynaud syndrome. Option A
is the best response.
Retrospective ECG gating is used for coronary CT angiography studies
performed on an MDCT scanner
[15]. Because the individual
coronary vessels have different motion patterns, performing individual
reconstruction for each vessel with regard to position in the cardiac cycle
may optimize coronary segment visualization. The right coronary artery is best
seen in early diastole, the left circumflex artery is best seen in mid cycle,
and the left anterior descending artery is best seen in late diastole
[16]. Option B is not the
best response.
Calcium deposits in the coronary arteries attenuate the X-ray beam,
resulting in beam-hardening and partial volume artifacts. Extensive
calcification may interfere with accurate assessment of stenosis
[17,
18]. Option C is not the
best response.
Scanning with 16-MDCT using standard protocols for coronary CT angiography
(120 kV, 400 mAs, 12 x 0.75 mm collimation) results in an effective
radiation dose of 8.1 mSv for men and 10.9 mSv for women
[19]. This dose is higher than
that of selective conventional coronary angiography (3-5 mSv). Option D is
not the best response.
Coronary arteries are small and move rapidly. Thus, imaging of the coronary
arteries requires high spatial and high temporal resolutions. Invasive,
catheter-based coronary angiography has a temporal resolutions ("shutter
speed") of approximately 6 milliseconds and a spatial resolution of
approximately 0.25 mm [20].
The current generation of 64-MDCT scanners allow an isotropic resolution of
0.4 x 0.4 x 0.4 mm at a gantry rotation speed of 330 milliseconds
[21]. By applying a half-scan
algorithm (only data from a 180° gantry rotation are used for image
reconstruction), acquisition time can be reduced to 165 milliseconds. Thus,
temporal and spatial resolutions of CT angiography are still inferior to those
of conventional angiography. Option E is not the best response.
Solution to Question 6
Evaluation of coronary bypass grafts is one of the first widely accepted
indications for contrast-enhanced CT angiography
[22]. CT with ECG gating may
be particularly useful in symptomatic patients during the immediate
postoperative setting, not only to evaluate graft patency but also to evaluate
for other conditions that can elicit similar symptoms to those of graft
stenosis or occlusion, such as pericardial effusion, pleural effusion, sternal
infection, and pulmonary embolism
[23]. Delayed complications,
including late-onset graft occlusion or aneurysm formation, are also well
evaluated with CT. Further, if a revision or repeat bypass surgery is needed,
CT is useful in delineating the existing grafts and complex postoperative
anatomy for planning before the procedure
[23]. An emerging application
is 3D-rendered volumetric CT of the thorax and coronary arteries before the
initial bypass surgery, especially with the advent of minimally invasive
direct coronary artery bypass (MIDCAB)
[22]. Option A is not the
best response.
In the United States, up to two thirds of conventional cardiac angiograms
are obtained solely for diagnostic purposes. With the latest generation of
MDCT scanners, CT has become the noninvasive technique of choice for
evaluating coronary artery stenosis. Sensitivity ranges between 80% and 90%
for hemodynamically significant proximal coronary artery stenosis
[22]. Furthermore, a high
negative predictive value (reported to be 97% with 16-MDCT) suggests a role
for noninvasive CT coronary angiography to rule out significant coronary
artery disease in patients with equivocal clinical presentations and findings
[22]. Option B is not the
best response.
Cross-sectional imaging has been recognized as the preferred diagnostic
strategy for the evaluation of coronary artery anomalies
[22]. MRI is an excellent
technique for evaluating suspected coronary artery anomalies; however, MRI has
shown limitations in determining the distal course of the coronary vessels
[23]. Therefore, CT is
preferred for evaluating small collaterals, fistulas, aneurysms, and vessels
originating outside the normal sinuses
[22]. Option C is not the
best response.
Coronary artery CT has no role in the management of acute myocardial
infarction when the diagnosis can be established by clinical features,
elevation of cardiac enzymes, and typical ECG changes. Option D is the best
response.
Pulmonary veins are an important source of ectopic atrial electrical
activity, causing atrial fibrillation. CT is ideally suited for noninvasive
visualization of the pulmonary venous return and the left atrium before
ablation therapy [22].
Option E is not the best response.
Solution to Question 7
Patients presenting with acute chest pain are more likely to have rapid,
irregular heart rates and are unlikely to be able to perform a lengthy
breath-hold. The use of slower, older-generation CT scanners is therefore not
practical. With the CT scanners now availablenamely,
64-MDCTtemporal resolution is vastly improved, thereby decreasing
breath-hold times and achieving diagnostic examinations even with higher, more
irregular heart rates [22,
24]. Option A is not the
best response.
CT angiography is best indicated for patients with an equivocal
presentation, nondiagnostic ECG, and initially negative serum markers for
acute myocardial infarctions. Those patients with a high pretest probability
of coronary artery disease (unstable angina with known coronary disease, sinus
tachycardia, ischemic ECG changes, or positive cardiac enzyme markers) will
likely require a conventional workup, including catheter angiography.
Option B is not the best response.
With the use of 64-MDCT scanners, the concept of extending cardiac
angiography to include the pulmonary arteries and the thoracic aorta has been
actively discussed. The ability to evaluate for hemodynamically significant
coronary artery stenosis, pulmonary embolism, and thoracic aortic dissection
has obvious appeal to the emergency department clinician. However, adequately
evaluating for these entities with one examination would require a much larger
field of view and volume of coverage as well as a longer bolus of IV contrast
material to enhance both the pulmonary and thoracic vasculature
[24]. Before implementation,
this protocol needs to be compared with the standard individual examinations,
and the clinical indication for this type of examination must be carefully
defined [22,
24]. Option C is the best
response.
CT coronary angiography has a high negative predictive value; therefore,
significant coronary artery disease in patients with acute chest pain should
be safely ruled out by a negative examination
[22]. Option D is not the
best response.
Acute chest pain is a common presenting symptom in emergency department
patients. Most patients will not actually have coronary syndromes. Option E
is not the best response.
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