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Fig. 4C —Use of 
ß3
integrin-targeted microbubbles to directly depict angiogenesis in
intracerebral gliomas in rats. (Reprinted with permission from Ellegala DB,
Leong-Poi H, Carpenter JE, et al. Imaging tumor angiogenesis with contrast
ultrasound and microbubbles targeted to
ß3. Circulation 2003;
108:336-341 [49].) Color-coded
map of signal enhancement produced by microbubbles that corresponds to
A. This map, in which greatest signal enhancement is shown in white and
less profound signal enhancement in red, shows regions of prominent
microbubble deposition, indicating areas of marked angiogenesis.
