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Fig. 5A —Direct imaging of angiogenesis in mouse model of
atherosclerosis using MRI and paramagnetic nanoparticles targeted against
ß3 integrin. (Reprinted with permission
from Winter PM, Morawski AM, Caruthers SD, et al. Molecular imaging of
angiogenesis in early-stage atherosclerosis with
ß3-integrin-targeted nanoparticles.
Circulation 2003; 108:2270-2274
[51].) Axial image through
aorta using T1-weighted spin-echo fat-suppressed black-blood imaging before
administration of targeted paramagnetic nanoparticles shows walls of aorta
(arrowhead) are relatively isointense to surrounding tissue.
