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Fig. 6 —Direct imaging of angiogenesis in rabbit tumor model using
MRI and paramagnetic nanoparticles targeted against
ß3 integrin. Color-coded
contrast-enhanced T1-weighted image of carcinoma implanted in rabbit shows
areas of contrast enhancement coded by yellow pixels, which represent
deposition of nanoparticles in regions of angiogenesis. Note that distribution
is preferentially in tumor periphery. (Reprinted with permission from Winter
PM, Caruthers SD, Kassner A, et al. Molecular imaging of angiogenesis in
nascent Vx-2 rabbit tumors using a novel
ß3-targeted nanoparticle and 1.5 Tesla
magnetic resonance imaging. Cancer Res 2003; 63:5838-5843
[52].)
