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Fig. 3B —Use of photoacoustic imaging to depict angiogenesis after
subcutaneous injection of pancreatic tumor cells in a rat. Using this
technique, light is converted into sound by optical absorption. A laser serves
as light source; light, which is predominantly absorbed by hemoglobin, causes
small focal temperature increase and restriction in dilation of RBCs. In turn,
local pressure increases are generated, producing ultrasonic waves that allow
3D reconstruction of position of blood vessels. Regions of maximal acoustic
source strength are shown in red, followed by yellow. (Reprinted with
permission from Siphanto RI, Thumma KK, Kolkman RGM, et al. Serial noninvasive
photoacoustic imaging of neovascularization in tumor angiogenesis. Optics
Express 2005; 13:89-95
[45].) On day 7 after tumor
implantation, regions of prominent angiogenesis are present throughout much of
image.
