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Fig. 4A —Use of 
ß3
integrin-targeted microbubbles to directly depict angiogenesis in
intracerebral gliomas in rats. (Reprinted with permission from Ellegala DB,
Leong-Poi H, Carpenter JE, et al. Imaging tumor angiogenesis with contrast
ultrasound and microbubbles targeted to
ß3. Circulation 2003;
108:336-341 [49].)
Contrast-enhanced sonogram of blood flow in coronal plane shows tumor mass (T)
and metastasis (M) adjacent to cerebral ventricles (V).
