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Fig. 2A —19-year-old man with glioblastoma multiforme. Two types of infusion
failure were seen in this patient. Forty-eight hours after initiation of
convection-enhanced infusion, leakage of infusate into subarachnoid CSF space
occurred, and hyperintense signal did not develop on T2-weighted MR images.
A-C, Images show failure due to catheter crossing sulcus within
backflow region. D-F, Images show failure due to placement of catheter
tip within subarachnoid space. Human figure indicates imaging plane. Blue line
and indicates plane perpendicular to catheter shown in C and F.
Thick red and thicker and lighter blue indicate catheter trajectories. Oblique
sagittal T2-weighted image shows trajectory of catheter (red line)
and superimposed coregistered SPECT signal (yellow outline) around
tip of catheter at 50% isodose level. Catheter tip is inappropriately adjacent
to sulcus.
