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Fig. 9 —Monitoring early rheumatoid arthritis activity. Schematic of
quantitative evaluation of rate of synovial enhancement before (solid
line) and after (dotted line) effective treatment. Data were
derived from contrast-enhanced dynamic MRI scans. Synovial enhancement is
defined as SIt – SI0 /
t, where SIt is signal
intensity obtained t seconds after contrast injection,
SI0 is signal intensity obtained in first unenhanced
image, and
t is time taken to reach peak
enhancement over initial linear phase (dotted area). After treatment,
synovitis and therefore synovial enhancement are reduced.