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DOI:10.2214/AJR.06.1589
AJR 2008; 190:W73
© American Roentgen Ray Society

Fibrosing Colonpathy in Adults with Cystic Fibrosis

Allan S. Brett

University of South Carolina, School of Medicine, Columbia, SC 29203

Elizabeth H. Mack

University of Cincinnati College of Medicine, Cincinnati, OH 45267



 
WEB—This is a Web exclusive article.

In their pictorial essay on abdominal manifestations of cystic fibrosis in older children and adults, Fields and colleagues [1] stated that "fibrosing colonopathy has not been reported in adults." However, we [2] recently reported the case of a 25-year-old man with cystic fibrosis who underwent right hemicolectomy for gradually progressive bowel obstruction. Histologic examination of the resected specimen was consistent with fibrosing colonopathy. It is unclear whether previous exposure to high-dose pancreatic enzyme supplements, recurrent intestinal injury from impacted material, or other mechanisms were involved in the pathogenesis of the patient's fibrosing colonopathy. In our case report, we noted one other adult with cystic fibrosis and fibrosing colonopathy, reported in 1998 [3].


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  1. Fields TM, Michel SJ, Butler CL, Kriss VM, Albers SL. Abdominal manifestations of cystic fibrosis in older children and adults. AJR 2006; 187:1199 -1203[Abstract/Free Full Text]
  2. Mack EH, Brett AS, Brown D. Fibrosing colonopathy in an adult cystic fibrosis patient after discontinuing pancreatic enzyme therapy. South Med J 2004;97 : 901-904[CrossRef][Medline]
  3. Häusler M, Meilicke R, Biesterfeld S, et al. First adult patient with fibrosing colonopathy. Am J Gastroenterol1998; 93:1171 -1172[Medline]

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