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Fig. 3 —Photomicrograph shows histology of nonalcoholic
steatohepatitis in 62-year-old woman. Mallory's hyaline bodies (pink
filamentous structures, black arrowhead) are cytoplasmic inclusions
in hepatocytes consisting of abnormal keratin, hyaline, and other proteins.
They are usually found in hepatocytes that are ballooned (black
arrow) and are morphologic hallmarks of alcoholic and nonalcoholic
steatohepatitis. Mallory's bodies are not cause but rather consequence of
cellular injury. Usually hepatocytes with Mallory's bodies do not contain
large fat vacuoles, although microvesicular fat may be seen. In this frame,
other hepatocytes are present, containing macrovesicular fat globules
(white arrow), which occupy almost all cytoplasm, displacing nucleus
(white arrowhead) to periphery. (H and E, x 400) (Courtesy of
Romil Saxena, Department of Pathology, Indiana Universtiy School of
Medicine)
