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Fig. 1 —Analysis of kinetics with signal enhancement ratio. Graph
shows signal intensity (S) versus time (t). S0, S1, and
S2 represent signal intensity of images obtained at t0
(before contrast injection), t1 (2.5 minutes after contrast
injection), and t2 (7.5 minutes after contrast injection),
respectively. Three curves display different patterns of signal increase and
washout that are seen with time: bottom curve shows slow gradual increase in
enhancement, more characteristic of normal tissue; middle curve shows early
enhancement with little washout, essentially a plateau in signal intensity;
top curve shows pattern of early enhancement with quick washout, which is more
characteristic of highly vascularized tissue and neoangiogenic vessels. Signal
enhancement ratio is measured as the increase in signal intensity at
t1 relative to baseline (t0) divided by increase from
baseline to t2: (S1 -
S0)/(S2 - S0).
