Breast patterns as an index of risk for developing breast cancer

The radiographic appearance of the breast parenchyma provides a method of predicting who will develop a breast cancer. This paper describes a restrospective study of 7,214 patients. On the basis of the radiographic appearance of the breast parenchyma, patients were placed into one of four groups of risk for developing carcinoma of the breast. Follow-up studies revealed a stepwise progression in the incidence of developing carcinoma of the breast at least 6 months after the radiographic examination. In one of the two substudies, there was a 37 times greater incidence for those at highest risk compared to the low risk group. The classifications presented are thought to be of value in the everyday practice of mammography as well as in planning screening programs.
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				C. M. Vachon, L. H. Kushi, J. R. Cerhan, C. C. Kuni, and T. A. Sellers Association of Diet and Mammographic Breast Density in the Minnesota Breast Cancer Family Cohort Cancer Epidemiol. Biomarkers Prev., February 1, 2000; 9(2): 151 - 160. [Abstract] [Full Text]

				R. Jakes, S. Duffy, F. Ng, F Gao, and E. Ng Mammographic parenchymal patterns and risk of breast cancer at and after a prevalence screen in Singaporean women Int. J. Epidemiol., February 1, 2000; 29(1): 11 - 19. [Abstract] [Full Text] [PDF]

				C. Atkinson, R. Warren, S. A. Bingham, and N. E. Day Mammographic Patterns as a Predictive Biomarker of Breast Cancer Risk: Effect of Tamoxifen Cancer Epidemiol. Biomarkers Prev., October 1, 1999; 8(10): 863 - 866. [Abstract] [Full Text]

				G. Liljegren, L. Holmberg, J. Bergh, A. Lindgren, L. Tabar, H. Nordgren, and H.O. Adami 10-Year Results After Sector Resection With or Without Postoperative Radiotherapy for Stage I Breast Cancer: A Randomized Trial J. Clin. Oncol., August 1, 1999; 17(8): 2326 - 2326. [Abstract] [Full Text] [PDF]

				C. J. Baines and R. Dayan A Tangled Web: Factors Likely to Affect the Efficacy of Screening Mammography J Natl Cancer Inst, May 19, 1999; 91(10): 833 - 838. [Full Text] [PDF]

				G. A. Greendale, B. A. Reboussin, A. Sie, H. R. Singh, L. K. Olson, O. Gatewood, L. W. Bassett, C. Wasilauskas, T. Bush, E. Barrett-Connor, et al. Effects of Estrogen and Estrogen-Progestin on Mammographic Parenchymal Density Ann Intern Med, February 16, 1999; 130(4_Part_1): 262 - 268. [Abstract] [Full Text] [PDF]

				I. T. Gram, E. Funkhouser, and L. Tabar Moderate Physical Activity in Relation to Mammographic Patterns Cancer Epidemiol. Biomarkers Prev., February 1, 1999; 8(2): 117 - 122. [Abstract] [Full Text]

				D. Franceschi, J. Crowe, R. Zollinger, R. Duchesneau, R. Shenk, G. Stefanek, and J. M. Shuck Breast Biopsy for Calcifications in Nonpalpable Breast Lesions: A Prospective Study Arch Surg, February 1, 1990; 125(2): 170 - 173. [Abstract] [PDF]

				T. Carlile, K. J. Kopecky, D. J. Thompson, J. R. Whitehead, F. I. Gilbert Jr, A. J. Present, B. A. Threatt, P. Krook, and E. Hadaway Breast Cancer Prediction and the Wolfe Classification of Mammograms JAMA, August 23, 1985; 254(8): 1050 - 1053. [Abstract] [PDF]

				L. Tabar and P. B. Dean Mammographic Parenchymal Patterns: Risk Indicator for Breast Cancer? JAMA, January 8, 1982; 247(2): 185 - 189. [Abstract] [PDF]

				D. S. Cukier, F. A. Lopez, and R. B. Maravilla Jr One-View Follow-up Mammogram: Efficacy in Screening for Breast Cancer JAMA, February 14, 1977; 237(7): 661 - 662. [Abstract] [PDF]