Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent

Chelation of the rare-earth element gadolinium (Gd) with diethylenetriaminepentaacetic acid (DTPA) results in a strongly paramagnetic, stable complex that is well tolerated in animals. The strongly paramagnetic gadolinium complex reduces hydrogen-proton relaxation times even in low concentrations (less than 0.01 mmol/L). The pharmacokinetic behavior of intravenously delivered Gd-DTPA is similar to the well known iodinated contrast agents used in urography and angiography; excretion is predominantly through the kidneys with greater than 90% recovery in 24 hr. The intravenous LD50 of the meglumine salt of Gd-DTPA is 10 mmol/kg for the rat; in vivo there is no evidence of dissociation of the gadolinium ion from the DTPA ligand. The combination of strong proton relaxation, in-vivo stability, rapid urinary excretion, and high tolerance favors the further development and the potential clinical application of gadolinium-DTPA as a contrast enhancer in magnetic resonance imaging.
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				A. Spencer, S. Wilson, and E. Harpur Gadolinium chloride toxicity in the mouse Human and Experimental Toxicology, November 1, 1998; 17(11): 633 - 637. [Abstract] [PDF]

				M. G. Friedrich, O. Strohm, J. Schulz-Menger, H. Marciniak, F. C. Luft, and R. Dietz Contrast Media–Enhanced Magnetic Resonance Imaging Visualizes Myocardial Changes in the Course of Viral Myocarditis Circulation, May 19, 1998; 97(18): 1802 - 1809. [Abstract] [Full Text] [PDF]

				K. Gaffney, J. Cookson, S. Blades, A. Coumbe, and D. Blake Quantitative assessment of the rheumatoid synovial microvascular bed by gadolinium-DTPA enhanced magnetic resonance imaging Ann Rheum Dis, March 1, 1998; 57(3): 152 - 157. [Abstract] [Full Text]

				A. J. Spencer, S. A. Wilson, J. Batchelor, A. Reid, J. Pees, and E. Harpur Gadolinium Chloride Toxicity in the Rat Toxicol Pathol, May 1, 1997; 25(3): 245 - 255. [Abstract] [PDF]

				R. J. Kim, E.-L. Chen, J. A.C. Lima, and R. M. Judd Myocardial Gd-DTPA Kinetics Determine MRI Contrast Enhancement and Reflect the Extent and Severity of Myocardial Injury After Acute Reperfused Infarction Circulation, December 15, 1996; 94(12): 3318 - 3326. [Abstract] [Full Text]

				T. Simor, W.-J. Chu, L. Johnson, A. Safranko, M. Doyle, G. M. Pohost, and G. A. Elgavish In Vivo MRI Visualization of Acute Myocardial Ischemia and Reperfusion in Ferrets by the Persistent Action of the Contrast Agent Gd(BME-DTTA) Circulation, December 15, 1995; 92(12): 3549 - 3559. [Abstract] [Full Text]

				E. E. van der Wall, H. W. Vliegen, A. de Roos, and A. V.G. Bruschke Magnetic Resonance Imaging in Coronary Artery Disease Circulation, November 1, 1995; 92(9): 2723 - 2739. [Abstract] [Full Text]

				H. Matsuoka, M. Hamada, T. Honda, H. Kawakami, H. Okayama, M. Abe, Y. Shigematsu, T. Sumimoto, and K. Hiwada Precise Assessment of Myocardial Damage Associated with Secondary Cardiomyopathies by Use of Gd-DTPA-Enhanced Magnetic Resonance Imaging Angiology, December 1, 1993; 44(12): 945 - 950. [Abstract] [PDF]

				M. Abrams and B. Murrer Metal compounds in therapy and diagnosis Science, August 6, 1993; 261(5122): 725 - 730. [Abstract] [PDF]

				L. Regli, F. Regli, P. Maeder, and J. Bogousslavsky Magnetic Resonance Imaging With Gadolinium Contrast Agent in Small Deep (Lacunar) Cerebral Infarcts Arch Neurol, February 1, 1993; 50(2): 175 - 180. [Abstract] [PDF]

				J. J. Mulvihill, D. M. Parry, J. L. Sherman, A. Pikus, M. I. Kaiser-Kupfer, and R. Eldridge Neurofibromatosis 1 (Recklinghausen Disease) and Neurofibromatosis 2 (Bilateral Acoustic Neurofibromatosis) An Update Ann Intern Med, July 1, 1990; 113(1): 39 - 52. [Abstract] [PDF]

				J. A. Clanton Magnetic Resonance Imaging Contrast Agents and the Nuclear Pharmacist Journal of Pharmacy Practice, January 1, 1989; 2(3): 191 - 195. [Abstract] [PDF]

				Council on Scientific Affairs Fundamentals of Magnetic Resonance Imaging JAMA, December 18, 1987; 258(23): 3417 - 3423. [Abstract] [PDF]

				G. K. Lund, C. B. Higgins, M. F. Wendland, N. Watzinger, H.-J. Weinmann, and M. Saeed Assessment of Nicorandil Therapy in Ischemic Myocardial Injury by Using Contrast-enhanced and Functional MR Imaging Radiology, December 1, 2001; 221(3): 676 - 682. [Abstract] [Full Text] [PDF]