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November 23, 2012
Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies
Authors: G Di Chiro, E Oldfield, DC Wright, D De Michele, DA Katz, NJ Patronas, JL Doppman, SM Larson, M Ito, and CV KuftaAuthor Info & Affiliations
Abstract
Cerebral necrosis after radiotherapy for brain tumors is being recognized as a problem more common than previously estimated. Distinction between this iatrogenic complication and tumor recurrence cannot be made by either CT or MR imaging. By using positron emission tomography (PET) with 18F-deoxyglucose (FDG) we were able to reach a diagnosis of radiation necrosis, later verified, in 10 of 95 patients referred for the purpose of differentiating tumor recurrence from necrosis. The critical PET-FDG feature was focal hypometabolism in the area of necrosis, which contrasted with the hypermetabolism associated with the residual/recurrent tumor. In addition, four cases of cerebral necrosis after supraophthalmic, intraarterial chemotherapy (BCNU) were studied with the PET-FDG method. The area of chemotherapy damage was also characterized by marked hypometabolism. Histology revealed both similarities and differences between radio- and chemonecrosis.
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© American Roentgen Ray Society.
History
First published: November 23, 2012
Authors
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G Di Chiro
Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
E Oldfield
Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
DC Wright
Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
D De Michele
Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
DA Katz
Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
NJ Patronas
Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
JL Doppman
Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
SM Larson
Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
M Ito
Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
CV Kufta
Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
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