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September 1989

The acetazolamide challenge: imaging techniques designed to evaluate cerebral blood flow reserve

Abstract

Cerebral blood flow was analyzed by the stable xenon (Xe)/CT scanning technique in 29 patients with significant vascular lesions before and after administration of an acetazolamide (Diamox) vasodilatory challenge. Three response types were identified: I, normal flow before Diamox with flow augmentation after Diamox; II, low flow before Diamox with flow augmentation after Diamox; and III, low or normal flow before Diamox with no augmentation or decreased flow after Diamox. Twenty-four percent of the patients studied qualified for category III. We believe that patients in this category represent a group of individuals without blood flow reserve whose clinical management should include careful consideration of their hemodynamic status. The Xe/CT scanning technique with the addition of Diamox flow challenge is a clinically accessible and effective method for assessing cerebral blood flow and blood flow reserve.

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Published In

American Journal of Roentgenology
Pages: 605 - 612
PubMed: 2763961

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Affiliations

J Rogg
Department of Radiology, Brown University School of Medicine, Rhode Island Hospital, Providence 02902.
M Rutigliano
Department of Radiology, Brown University School of Medicine, Rhode Island Hospital, Providence 02902.
H Yonas
Department of Radiology, Brown University School of Medicine, Rhode Island Hospital, Providence 02902.
DW Johnson
Department of Radiology, Brown University School of Medicine, Rhode Island Hospital, Providence 02902.
S Pentheny
Department of Radiology, Brown University School of Medicine, Rhode Island Hospital, Providence 02902.
RE Latchaw
Department of Radiology, Brown University School of Medicine, Rhode Island Hospital, Providence 02902.

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