CT colonography (CTC) is a CT examination, performed with low dose and typically without IV contrast media, optimized to detect colorectal polyps and cancer. Despite extensive supporting data, CTC has had variable acceptance and use over the past two decades, particularly for a main indication of colorectal cancer screening. CTC is now at an inflection point after the approval in 2025 by CMS for reimbursement of CTC performed for colorectal cancer screening. Widespread use of CTC for CRC screening could help increase screening adherence rates and prevent cancer incidence. Nonetheless, radiologists must incorporate emerging knowledge regarding polyps' natural history and recognition of sessile serrated lesions, to leverage the screening efficiencies of CTC-based screening. The purposes of this article are to describe the current status of CRC in the United States and United Kingdom with consideration of historical reasons that have limited the test's use along with recent events that may portend a marked change in the test's acceptance; to highlight the challenges and potential solutions toward successful widespread CTC implementation; and to present new concepts in CTC and CRC screening relevant to radiologists.