Review
Chest Imaging
July 2007

The Many Faces of Pulmonary Nontuberculous Mycobacterial Infection

Abstract

OBJECTIVE. The purpose of this article is to review clinical and radiologic manifestations of pulmonary nontuberculous mycobacterial infection.
CONCLUSION. Common and well-recognized patterns of infection include cavitary and bronchiectatic disease and infection in AIDS patients. Less common or well-recognized manifestations include nodules or masses mimicking malignancy, hypersensitivity pneumonitis, and others. Definitive diagnosis can be difficult and patterns may overlap. Timely diagnosis requires a high index of suspicion and knowledge of the spectrum of clinical and radiologic features.

Introduction

Nontuberculous mycobacteria were initially isolated shortly after Mycobacterium tuberculosis was isolated in the 19th century [1]. Although multiple reports in the first half of the 20th century describe human infection by “unusual,” “unclassified,” or “anonymous” mycobacteria, it was not until the 1950s that larger series began to confirm the nontuberculous mycobacteria as true human pathogens [1]. During the 1970s and early 1980s, Christensen et al. [2-4] showed the similarity of Mycobacterium avium-intracellulare complex (MAC) and Mycobacterium kansasii infection to postprimary pulmonary tuberculosis. This pattern of infection was subsequently termed “cavitary” or “classic” when an unusual form of the disease, later termed the “nonclassic” [5] or “bronchiectatic” [6] form, was described in the mid 1980s [7].

Epidemiology

By the early 1980s, the prevalence of non-tuberculous mycobacterial disease in the United States was estimated to be 1.8 cases per 100,000 inhabitants. Among nontuberculous mycobacterial isolates, mostly from respiratory secretions, 61% were MAC; 24%, M. kansasii; approximately 5%, Mycobacterium fortuitum; and 15%, other nontuberculous mycobacteria [8]. In the early 1980s, Zakowski et al. [9] reported an increasing incidence of MAC infection in patients with HIV infections. During the 1990s, analysis from the Centers for Disease Control and Prevention showed a dramatic increase in nontuberculous mycobacteria isolates to levels even higher than M. tuberculosis (MAC, 34% vs M. tuberculosis, 26%). Mycobacterium gordonae and M. fortuitum were identified in 18% and 5% of these isolates, respectively [10]. Although the exact reason for this apparent increased incidence is not clear, it is believed that increased clinical recognition and better techniques for diagnosis are at least partly responsible [11, 12].
Currently, MAC and, to a lesser extent, M. kansasii, account for most cases of nontuberculous mycobacteria infection among immunocompetent and immunosuppressed patients in the United States. Mycobacterium xenopi, Mycobacterium szulgai, and Mycobacterium simiae are less frequent causes of pulmonary disease. Mycobacterium scrofulaceum, Mycobacterium fortuitum-chelonei, and M. gordonae may also cause pulmonary disease but are more commonly isolated elsewhere in the body [5, 13].

Diagnosis

Definitive diagnoses of pulmonary nontuberculous mycobacteria infection are difficult. Because the organisms are often saprophytes, they may colonize airways rather than infect them. Cultures can be falsely positive in patients with chronic lung disease and falsely negative in infected patients without cavities [14]. Thus, identification of acid-fast bacilli at microscopy or isolation of nontuberculous mycobacteria in culture by itself is not enough evidence for establishing the diagnosis [6]. Further, there is cross-reactivity between MAC and M. tuberculosis on the purified protein derivative standard test [15]. Although many skin tests for diagnosis of nontuberculous mycobacteria, particularly MAC, have become available with good results, lack of standardization precludes their use in clinical practice [15].
Fig. 1A 54-year-old man with mild emphysema, cough, and fever. Cultures from sputum and resected surgical specimen showed Mycobacterium avium-intracellulare complex organisms. Chest radiograph coned to left upper lung shows well-circumscribed cavitary left upper lobe mass.
Fig. 1B 54-year-old man with mild emphysema, cough, and fever. Cultures from sputum and resected surgical specimen showed Mycobacterium avium-intracellulare complex organisms. Axial CT images (5-mm section, lung window setting) confirm left upper lobe cavity and show adjacent cluster of small nodules (arrows, C).
Fig. 1C 54-year-old man with mild emphysema, cough, and fever. Cultures from sputum and resected surgical specimen showed Mycobacterium avium-intracellulare complex organisms. Axial CT images (5-mm section, lung window setting) confirm left upper lobe cavity and show adjacent cluster of small nodules (arrows, C).
The American Thoracic Society (ATS) recently revised and simplified criteria for diagnosis of nontuberculous mycobacterial lung disease in HIV-seropositive and seronegative hosts (Appendix 1) [12].

Microbiologic Perspective

Traditionally, nontuberculous mycobacteria have been classified according to the Runyon system established in the 1950s. Four groups of nontuberculous mycobacteria, according to pigmentation and growth rate in culture, are recognized in this classification. The rapid-growers (group IV), as the name implies, can be grown in culture and identified in fewer than 7 days [16, 17]. Conversely, the slow-growers (groups I-III) take weeks to months to grow in culture. However, new molecular identification techniques that allow detection and speciation in a matter of hours are becoming more available [11, 18]. For these reasons, the Runyon system is becoming less important clinically [5, 6]. Speciation has important clinical and prognostic implications [19]. For example, infection with Mycobacterium abscessus, a group IV organism, tends to have an unpredictable response to medical treatment, and surgical resection may be attempted when feasible [16]. On the other hand, M. fortuitum, also a group IV organism, is more susceptible to medical therapy [11]. Further, conventional treatment for the slowly growing organisms MAC and M. kansasii are different. Most treatment regimens for M. kansasii include isoniazid, whereas those for MAC do not [11]. Thus, accurate and rapid speciation is becoming more important than classification according to the Runyon system. Also of interest is the lack of correlation between in vitro and in vivo susceptibility shown in some species of nontuberculous mycobacteria (e.g., M. xenopi and Mycobacterium malmoense) [20, 21], a fact that raises some concern regarding the importance of this test.

Clinical and Radiologic Manifestations

The clinical and radiologic manifestations of pulmonary nontuberculous mycobacteria infection are protean and include the cavitary (“classic”) form, bronchiectatic (“nonclassic”) form, infection in immunocompromised patients (HIV and non-HIV), nodules or masslike opacities, infection in patients with deglutition problems, and hypersensitivity pneumonitis [5, 14, 22]. However, these manifestations are not mutually exclusive; several forms can be seen in an individual patient. Moreover, new manifestations of disease are occasionally reported that do not easily fit into these categories. However, this classification is useful for purposes of discussion and differential diagnosis, and it will be used here. The cavitary and the bronchiectatic forms of the disease are responsible for most nontuberculous mycobacteria infections in the immunocompetent patient [2, 3, 7, 23, 24]. The true incidence of other forms of nontuberculous mycobacteria infection is unknown.

Cavitary Form (Classic Infection)

The clinical and radiologic manifestations of the cavitary (or classic) form of the disease are quite similar to those of postprimary tuberculosis. This form of the disease is more prevalent among older white men with underlying chronic pulmonary disease (e.g., chronic obstructive pulmonary disease) [2-4, 24]. Some important predisposing conditions for pulmonary nontuberculous mycobacteria infection are listed in Appendix 2 [6]. Most cases are caused by MAC, although M. kansasii, and, to a lesser extent, M. xenopi [21, 25-27], M. abscessus [28], and M. malmoense [20, 29], can also manifest with this pattern.
Common findings in the chest radiograph include upper lobe cavitary lesions and endobronchial spread evidenced by nodules adjacent to foci of disease (Figs. 1A, 1B, 1C, 2A, 2B, 2C, 3A, and 3B), cicatricial atelectasis, and pleural thickening. In comparison with postprimary tuberculosis, disease progresses more slowly [5, 14] and cavities are more likely to be smaller or thin-walled [2, 14, 23]. CT can further characterize cavities (usually single with ill-defined margins) and show associated bronchiectasis and pleural thickening [5, 30, 31]. As in tuberculosis, adenopathy and pleural effusion are uncommon manifestations [7, 24, 32, 33].
Fig. 2A 36-year-old woman with chronic cough, weight loss, and fatigue. Cultures from sputum showed Mycobacterium avium-intracellulare complex organisms. Frontal chest radiograph shows right upper lobe volume loss and bronchiectasis and poorly defined nodules in right lower lung. Note also left lower lobe volume loss, heterogeneous opacity, and left upper lobe bulla.
Fig. 2B 36-year-old woman with chronic cough, weight loss, and fatigue. Cultures from sputum showed Mycobacterium avium-intracellulare complex organisms. Axial CT image (5-mm section, lung window setting) shows small clustered right upper lobe nodules and cavity (arrow). Note left upper lobe bullae (asterisks).
Fig. 2C 36-year-old woman with chronic cough, weight loss, and fatigue. Cultures from sputum showed Mycobacterium avium-intracellulare complex organisms. Axial CT image (5-mm section, lung window setting) obtained at more caudal level shows right lower lobe tree-in-bud opacities (white arrows) consistent with endobronchial spread of infection. Note left lower lobe cavity (asterisk) and bronchiectasis (black arrow).
Fig. 3A 37-year-old man with chronic cough. Cultures of bronchoalveolar lavage fluid showed Mycobacterium chelonei organisms. Axial CT image (1.25-mm section, lung window setting) shows large cavity in right upper lobe with lobular intracavitary mass. Note ground-glass opacity in left upper lobe, possibly representing additional focus of infection. Histopathologic analysis of resected specimen showed necrotic lung in cavity.
Fig. 3B 37-year-old man with chronic cough. Cultures of bronchoalveolar lavage fluid showed Mycobacterium chelonei organisms. Axial CT image (1.25-mm section, lung window setting) obtained at more caudal level shows tree-in-bud opacities (arrows) consistent with endobronchial spread of infection.
Fig. 4 73-year-old woman with chronic productive cough and fatigue. Cultures of bronchoalveolar lavage fluid showed Mycobacterium avium-intracellulare complex organisms. Axial CT image (1.25-mm section, lung window setting) shows cylindric bronchiectasis (arrows) and partial volume loss in right middle lobe and lingula. Note bilateral lower lobe scattered nodules.
Fig. 5A 67-year-old woman with chronic cough and weight loss. Sputum cultures showed Mycobacterium avium-intracellulare complex organisms. Frontal chest radiograph shows hyperinflation and subtle opacity in right middle lobe. Note symmetric bilateral apical scarring.
Fig. 5B 67-year-old woman with chronic cough and weight loss. Sputum cultures showed Mycobacterium avium-intracellulare complex organisms. Lateral chest radiograph shows hyperinflation and atelectasis of right middle lobe.
Fig. 5C 67-year-old woman with chronic cough and weight loss. Sputum cultures showed Mycobacterium avium-intracellulare complex organisms. Axial CT images (1-mm section, lung window setting) show diffuse mosaic attenuation and bronchiectases. Note atelectasis of right middle lobe and small peripheral foci of consolidation in left upper lobe.
Fig. 5D 67-year-old woman with chronic cough and weight loss. Sputum cultures showed Mycobacterium avium-intracellulare complex organisms. Axial CT images (1-mm section, lung window setting) show diffuse mosaic attenuation and bronchiectases. Note atelectasis of right middle lobe and small peripheral foci of consolidation in left upper lobe.

Bronchiectatic (Nonclassic) Form

MAC and M. kansasii [7, 30, 31, 34-37] are the most common organisms responsible for this form of disease; however, other mycobacteria such as M. chelonae [38] and M. abscessus [16, 28, 39] can manifest in this way. The infection is more commonly seen among elderly white women with no predisposing factors [5, 7, 30, 31, 35, 36]. Whether the infection develops in the setting of preexisting bronchiectasis [34, 40, 41] or results in bronchiectasis [42] is controversial. However, some evidence indicates that bronchiectasis progresses more rapidly in the setting of infection with nontuberculous mycobacteria [34, 40]. Infection presents in an indolent fashion with a chronic cough; constitutional symptoms are uncommon [5, 35]. Some of these patients may voluntarily suppress their cough, leading to poor drainage of secretions and engraftment of nontuberculous mycobacteria, the so-called Lady Windermere syndrome [36, 43]. Because sputum cultures are not sensitive for diagnosis in this form of the disease, more invasive studies such as bronchoalveolar lavage and biopsy may be required [44]. On histopathologic examination, bronchiolectasis and bronchiolar and peribronchiolar inflammation with or without granuloma formation are seen [45].
Radiographic findings include randomly distributed nodular opacities; cavitation is uncommon [7]. CT characteristically shows small centrilobular nodules or tree-in-bud opacities, with cylindric bronchiectasis, usually in the same lobe [28, 30, 37, 42, 46] (Fig. 4). Although the right middle lobe and the lingula are most commonly affected [7, 36, 42, 46, 47], any segment can be involved [34, 40]. Other occasional findings include consolidation and ground-glass opacities [7, 30, 37, 38]. Atelectasis and mediastinal adenopathy are uncommon [5]. Recently it has been suggested that the coexistence of bronchiectasis and bronchiolitis (i.e., centrilobular nodules and a mosaic pattern) is highly suggestive of nontuberculous mycobacteria infection [48] (Figs. 5A, 5B, 5C, and 5D).
Fig. 6A 41-year-old man with AIDS, CD4 count of 166 cells/mL, and viral load of 153,000 cells/mL, with cough and fever. Cultures of sputum and histopathologic material obtained at mediastinal biopsy showed Mycobacterium avium-intracellulare complex organisms. Biopsies were negative for neoplasm. Frontal chest radiograph shows left-sided mediastinal and upper lobe mass (arrow). Note also subtle left upper lobe reticular opacities.
Fig. 6B 41-year-old man with AIDS, CD4 count of 166 cells/mL, and viral load of 153,000 cells/mL, with cough and fever. Cultures of sputum and histopathologic material obtained at mediastinal biopsy showed Mycobacterium avium-intracellulare complex organisms. Biopsies were negative for neoplasm. Axial CT image (5-mm section, soft-tissue window setting) shows bilateral paratracheal adenopathy (asterisks) and left upper lobe invading mediastinum (arrows).
Fig. 6C 41-year-old man with AIDS, CD4 count of 166 cells/mL, and viral load of 153,000 cells/mL, with cough and fever. Cultures of sputum and histopathologic material obtained at mediastinal biopsy showed Mycobacterium avium-intracellulare complex organisms. Biopsies were negative for neoplasm. Axial CT image (5-mm section, lung window setting) obtained at more caudal level shows tree-in-bud opacities in superior segments of both lower lobes (arrows).

HIV Patients

Infection by nontuberculous mycobacteria in HIV-infected patients is characterized by disseminated disease [49]. MAC is the most common nontuberculous mycobacteria agent identified in patients with AIDS and is frequently cultured from blood, bone marrow, lung, liver, spleen, and lymph nodes [9, 49]. During the 1990s, the lifetime prevalence of the disease among homosexual men was near 30% [50, 51]. MAC infection occurs in the setting of low CD4 counts (usually < 100 cells/mm3) [52]. The gastrointestinal tract is thought to be the source of infection, with eventual dissemination by bacteremia [52, 53]. The clinical picture consists of systemic symptoms such as fever, weight loss, fatigue, abdominal pain, and diarrhea. Lymphadenopathy and hepatosplenomegaly are common findings on physical examination. The diagnosis is usually established by culture of blood, bone marrow, or other sterile body site [52].
Fig. 7A 27-year-old man with AIDS and low CD4 count (< 40 cells/mL) treated with highly active antiretroviral therapy. Despite favorable immune response, patient developed fever and back pain. Cultures of histopathologic material obtained from retroperitoneal lymph node biopsy showed Mycobacterium avium-intracellulare complex organisms. Frontal chest radiograph shows bilateral bulky mediastinal lymphadenopathy. Clinical and imaging findings are consistent in showing immune reconstitution syndrome. Repeat radiographs after treatment (not shown) showed decreased mediastinal adenopathy.
Fig. 7B 27-year-old man with AIDS and low CD4 count (< 40 cells/mL) treated with highly active antiretroviral therapy. Despite favorable immune response, patient developed fever and back pain. Cultures of histopathologic material obtained from retroperitoneal lymph node biopsy showed Mycobacterium avium-intracellulare complex organisms. Axial CT image (5-mm section, soft-tissue window setting) obtained in upper abdomen shows extensive retroperitoneal and mesenteric adenopathy (asterisks).
Fig. 8A 70-year-old asymptomatic man with pulmonary nodule found on routine chest radiograph (not shown). Histopathologic analysis of resected specimen showed granulomatous inflammation and no evidence of malignancy. Cultures showed Mycobacterium avium-intracellulare complex organisms. Axial CT image (3.75-mm section, lung window setting) (A) and fused axial image from combined 18F-FDG PET/CT (B) show spiculated right upper nodule with significant FDG uptake.
Fig. 8B 70-year-old asymptomatic man with pulmonary nodule found on routine chest radiograph (not shown). Histopathologic analysis of resected specimen showed granulomatous inflammation and no evidence of malignancy. Cultures showed Mycobacterium avium-intracellulare complex organisms. Axial CT image (3.75-mm section, lung window setting) (A) and fused axial image from combined 18F-FDG PET/CT (B) show spiculated right upper nodule with significant FDG uptake.
Because MAC infection frequently coexists with other pulmonary infections (e.g., cytomegalovirus, pyogenic bacteria, Pneumocystis jiroveci, Candida albicans, Cryptosporidium organisms, and so forth) or even neoplasms (e.g., Kaposi sarcoma) [9, 49, 54, 55], pure radiographic findings are difficult to determine. Cases with MAC infection and no coexistent pulmonary infection are scant. In these reports, however, mediastinal lymphadenopathy seems to be the most common manifestation, with airspace opacities, miliary nodules, and pleural effusion reported infrequently. Normal chest radiographic findings are not infrequent [5, 49, 54, 55] (Figs. 6A, 6B, and 6C).
M. xenopi can also cause disseminated disease in patients with HIV [56]. Radiologic findings include heterogeneous peribronchial opacities, reticular opacities, miliary nodules, cavitation, atelectasis, pleural thickening, and lymphadenopathy [56, 57]. In patients with AIDS, infection with M. kansasii tends to be confined to the lungs. Reported radiographic findings include unifocal and unilateral alveolar opacities, mediastinal and hilar adenopathy, cavitation, and pleural effusion [58].
Recently, the immune reconstitution syndrome has been described in patients with HIV weeks to months after starting highly active antiretroviral therapy. This entity has been described with a variety of pathogens such as MAC, tuberculosis, Cryptococcus neoformans, cytomegalovirus, P. jiroveci, diverse viruses, and even inflammatory diseases such as sarcoidosis [59]. The immune reconstitution syndrome consists of an inflammatory response accompanied by clinical deterioration related to a wide range of inflammatory reactions in diverse organs directed against different preexisting microorganisms in tissues [59]. Thoracic disease manifests with cough or wheezing, fever, night sweats, dyspnea, weight loss, and chest pain. Radiographic and CT findings include mediastinal and hilar lymphadenopathy that may exhibit hypoattenuating centers, parenchymal opacities, cavitation, nodules, endobronchial nodules, tree-in-bud opacities, and pericardial effusion [60] (Figs. 7A and 7B).

Non-HIV Immunocompromised Patients

Disseminated nontuberculous mycobacteria infection in the non-HIV immunocompromised patient occurs in the setting of cytotoxic chemotherapy, solid organ transplantation, chronic corticosteroid therapy, leukemia, lymphoma, and so forth [61-63]. Although MAC and M. kansasii appear to be the most common infecting organisms, M. gordonae, Mycobacterium chelonei, and M. fortuitum have also been implicated [49, 61-63]. Clinical manifestations are nonspecific and include fever, weight loss, and malaise [49]. The lungs and the gastrointestinal tract appear to be the most likely source of disseminated infection, with hematogenous spread a posteriori [49]. Nontuberculous mycobacteria are more frequently cultured in bone marrow, sputum or lung, liver, spleen, and lymph nodes [49, 61, 62]. Unfortunately, reports of radiographic findings in this setting are limited and include reticular and nodular opacities, cavities, and mediastinal and hilar adenopathy [61, 63].

Nodules or Masses in Asymptomatic Patients

Pulmonary nontuberculous mycobacteria infection can manifest as nodules or masses in asymptomatic patients [64, 65] (Figs. 8A, 8B, 9A, and 9B). In a series of 20 patients with resected solitary pulmonary nodules caused by nontuberculous mycobacteria, MAC was cultured in 12 (60%) [66]. When multiple, nodules are usually clustered together and have a uniform size, a somewhat helpful feature for differentiation from malignancy. CT may show intralesional calcification or increased attenuation suggestive of a granulomatous cause [5, 14]. Both have 18F-FDG and 11C-choline focal uptake has been described in these nodules [65, 67]; however, the degree of uptake is usually less than that seen in cancer and tuberculosis [65].
Fig. 9A 42-year-old asymptomatic woman with multiple nodules found on routine chest radiograph. Cultures of histopathologic material obtained by fine-needle biopsy showed Mycobacterium xenopi organisms. Frontal chest radiograph shows multiple bilateral pulmonary nodules.
Fig. 9B 42-year-old asymptomatic woman with multiple nodules found on routine chest radiograph. Cultures of histopathologic material obtained by fine-needle biopsy showed Mycobacterium xenopi organisms. Axial CT image (2-mm section, lung window setting) shows bilateral, irregularly marginated nodules in both upper lobes.
Fig. 10 Young man with achalasia, fever, and cough. Culture of bronchoalveolar lavage fluid was positive for Mycobacterium fortuitum. Frontal chest radiograph shows dilated esophagus (white arrows). Note cluster of small nodules in right upper lobe (black arrows).

Infection in Patients with Deglutition Problems

By the late 1990s, at least 20 cases of diffuse pulmonary infection caused by rapidly growing mycobacteria in patients with esophageal motility disorders had been reported [68]. M. fortuitum and M. chelonae account for most isolates in this setting. Associated esophageal disorders include achalasia, hiatal hernia, dysmotility due to stroke or Parkinson's disease, and colonic interposition. Infection may complicate areas of lipid pneumonia [68]. The clinical presentation frequently includes fever, cough, weight loss, night sweats, hemoptysis, and dyspnea. Radiologic findings include unilateral or bilateral heterogeneous reticulonodular or alveolar opacities without lobar predominance. Pleural effusion was present in 20% and cavitary disease in 15% of reported cases [68, 69] (Fig. 10).

Hypersensitivity Pneumonitis

By 2005, at least 37 cases of hypersensitivity pneumonitis associated with inhaled MAC, often from hot tub exposure, had been described [22]. Affected patients present with dyspnea, cough, and fever [22]. Pulmonary function tests show either an obstructive or a restrictive pattern, often with an impaired diffusion capacity for carbon monoxide [22]. Lung biopsies show features of hypersensitivity pneumonitis and cultures frequently grow MAC. However, whether this phenomenon represents true hypersensitivity pneumonitis or infection remains controversial [22, 70-74]. MAC has been shown to exist in natural sea water and in fresh water [75, 76] and can become concentrated in hot water systems [77]. Water jets from hot tubs are thought to promote aerosol formation of bacteria that eventually travel to the lung by inhalation [71, 77]. Affected patients have been treated with or without corticosteroids or antimycobacterial therapy with equally good results if removal from the source of exposure (i.e., the hot tub) is achieved [71, 72]. M. chelonae has been associated with hypersensitivity pneumonitis among workers exposed to metalworking fluid in the automotive industry [78, 79].
Chest radiographs usually show abnormal findings, including diffuse fine nodular and reticulonodular opacities, diffuse opacities, and areas of consolidation. Characteristic CT findings include ill-defined, ground-glass centrilobular nodules (Fig. 11), more diffuse ground-glass opacities, and air trapping on expiratory examination [22, 80].
Fig. 11 Middle-aged man with cough, fever, and dyspnea who recently purchased indoor hot tub. Histopathologic analysis of lung biopsy specimen showed features of hypersensitivity pneumonitis; cultures of bronchoalveolar lavage fluid showed Mycobacterium avium-intracellulare complex organisms. Axial high-resolution CT image (1.25-mm section, lung window setting) of chest shows diffusely distributed ground-glass nodules. Clinical, imaging, and histopathologic features are consistent with “hot tub lung.”

Conclusion

Pulmonary nontuberculous mycobacteria infection is an increasingly important cause of morbidity and even mortality. The clinical and radiographic manifestations of infection are variable and frequently overlap. Diagnosis may be difficult and delayed, but consideration of nontuberculous mycobacteria disease as a possible diagnosis is the first step toward making the correct diagnosis and instituting appropriate treatment. Cooperation of pulmonary physicians and radiologists is mandatory because fiberoptic bronchoscopy with bronchoalveolar lavage or transbronchial lung biopsy is often the next most appropriate step after radiologic imaging for securing a definitive diagnosis.

APPENDIX 1: American Thoracic Society Criteria for Diagnosis of Pulmonary Nontuberculous Mycobacterial Infection (Adapted from [12])

Clinical Criteria

Pulmonary symptoms with
- Nodular or cavitary opacities on chest radiography, or
- Multifocal bronchiectasis with multiple small nodules on high-resolution CT

AND

Appropriate exclusion of other diagnoses

Microbiologic Criteria

Positive culture from at least two separate sputum samples

OR

Positive culture from at least one bronchial wash or lavage

OR

Transbronchial or other lung biopsy with mycobacterial features (granulomatous inflammation or acid-fast bacillus) and positive for nontuberculous mycobacteria or biopsy showing mycobacterial histopathologic features (granulomatous inflammation or acid-fast bacillus) and one or more sputum or bronchial washings that are culture-positive for nontuberculous mycobacteria

Note:

Expert consultation should be obtained when nontuberculous mycobacteria are recovered that are either infrequently encountered or usually representative of environmental contamination.
Patients who are suspected of having nontuberculous mycobacteria lung disease but do not meet the diagnostic criteria should be followed up until the diagnosis is firmly established or excluded.
Making the diagnosis of nontuberculous mycobacteria lung disease does not, per se, necessitate the institution of therapy, which is a decision based on the potential risks and benefits of therapy for the individual patient.

APPENDIX 2: Common Predisposing Conditions for Pulmonary Nontuberculous Mycobacterial Infection (Adapted from [6])

Underlying Lung Disease

Chronic obstructive pulmonary disease
Prior tuberculosis
Prior chest surgery
Lung carcinoma
Interstitial lung disease
Cystic fibrosis

Occupational Risk Factors

Mining
Welding
Sandblasting
Painting

Other

Immune Deficiency
Congenital
AIDS
Organ transplants
Corticosteroid administration
Achalasia
Previous gastrectomy
Renal failure, dialysis patients
Scoliosis, pectus excavatum
Collagen vascular disorders
Advancing age
Alcohol abuse
Smoking

Footnotes

Address correspondence to S. Martinez.
CME
This article is available for CME credit. See www.arrs.org for more information.

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Information & Authors

Information

Published In

American Journal of Roentgenology
Pages: 177 - 186
PubMed: 17579169

History

Submitted: February 19, 2007
Accepted: February 22, 2007
First published: November 23, 2012

Keywords

  1. chest
  2. lung
  3. mycobacterial infection

Authors

Affiliations

Santiago Martinez
Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710.
H. Page McAdams
Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710.
Chandra S. Batchu
Department of Radiology, St. Francis Hospital, Evanston, IL.

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